Dec 8, 2009
Delivery of the photosensitizer Pc 4 in PEG-PCL micelles for in vitro PDT studies.
J Pharm Sci . 2009 Dec 4; Master AM, Rodriguez ME, Kenney ME, Oleinick NL, Gupta AS The silicon phthalocyanine Pc 4 is a second-generation photosensitizer that has several properties superior to other photosensitizers currently approved by the FDA, and it has shown significant promise for photodynamic therapy (PDT) in several cancer cells in vitro and model tumor systems in vivo. However, because of the high hydrophobicity of Pc 4, its formulation for in vivo delivery and favorable biodistribution become challenging