J Neurosci Res . 2009 Dec 8; Yokoyama H, Kuroiwa H, Tsukada T, Uchida H, Kato H, Araki T An excessive expression of poly(ADP-ribose)polymerase (PARP) has been demonstrated to play a key role in the pathogenesis of Parkinson’s disease (PD).

J Neurosci Res . 2009 Dec 8; Cho Y, Shi R, Ivanisevic A, Ben Borgens R The mechanical damage to neurons and their processes induced by spinal cord injury (SCI) causes a progressive cascade of pathophysiological events beginning with the derangement of ionic equilibrium and collapse of membrane permeability

J Neurosci Res . 2009 Dec 8; Soane L, Li Dai W, Fiskum G, Bambrick LL Oxidative stress is a mediator of cell death following cerebral ischemia/reperfusion and heme toxicity, which can be an important pathogenic factor in acute brain injury.

J Neurosci Res . 2009 Dec 8; Leonardo CC, Hall AA, Collier LA, Ajmo CT, Willing AE, Pennypacker KR Secondary neurodegeneration resulting from stroke is mediated by delayed proinflammatory signaling and immune cell activation. Although it remains unknown which cell surface markers signify a proinflammatory phenotype, increased isolectin binding occurs on CD11b-expressing immune cells within injured brain tissue

J Neurosci Res . 2009 Dec 8; Yoneyama M, Kawada K, Ogita K In adults, the subventricular zone is known to contain undifferentiated neural progenitor cells that proliferate and generate the olfactory bulb (OB) interneurons throughout life. We earlier showed that trimethyltin (TMT) causes neuronal damage in the granular cell layer of the OB in adult mice